Male breast cancer in BRCA1 and BRCA2 mutation carriers: Pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 Academic Article uri icon

Overview

MeSH Major

  • BRCA1 Protein
  • BRCA2 Protein
  • Breast Neoplasms
  • Breast Neoplasms, Male

abstract

  • On the basis of the largest series analysed to date, our results show that BRCA1/2 MBCs display distinct pathologic characteristics compared with BRCA1/2 FBCs, and we identified a specific BRCA2-associated MBC phenotype characterised by a variable suggesting greater biological aggressiveness (i.e., high histologic grade). These findings could lead to the development of gender-specific risk prediction models and guide clinical strategies appropriate for MBC management.

authors

publication date

  • February 9, 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4746828

Digital Object Identifier (DOI)

  • 10.1186/s13058-016-0671-y

PubMed ID

  • 26857456

Additional Document Info

start page

  • 15

volume

  • 18

number

  • 1