Diverse and targetable kinase alterations drive histiocytic neoplasms Academic Article uri icon

Overview

MeSH Major

  • Gene Expression Profiling
  • Histiocytosis, Langerhans-Cell
  • Histiocytosis, Non-Langerhans-Cell
  • Mutation
  • Sequence Analysis, DNA

abstract

  • We provide the first description of kinase fusions in systemic histiocytic neoplasms and activating ARAF and MAP2K1 mutations in non-Langerhans histiocytic neoplasms. Refractory patients with MAP2K1- and ARAF-mutant histiocytoses had clinical responses to MEK inhibition and sorafenib, respectively, highlighting the importance of comprehensive genomic analysis of these disorders.

authors

publication date

  • February 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4744547

Digital Object Identifier (DOI)

  • 10.1158/2159-8290.CD-15-0913

PubMed ID

  • 26566875

Additional Document Info

start page

  • 154

end page

  • 65

volume

  • 6

number

  • 2