Leaky gut-concept or clinical entity? Review uri icon

Overview

MeSH Major

  • Gastric Mucosa
  • Gastrointestinal Absorption
  • Gastrointestinal Tract
  • Immunity, Mucosal
  • Inflammatory Bowel Diseases

abstract

  • Although several aspects of barrier function can be assessed in man, one must be aware of exactly what a given test measures, as well as of its limitations. The temptation to employ results from a test of paracellular flux to imply a role for barrier dysfunction in disorders thought to be based on bacterial or macromolecular translocation must be resisted. Although changes in barrier function have been described in several gastrointestinal disorders, their primacy remains to be defined. At present, few studies support efficacy for an intervention that improves barrier function in altering the natural history of a disease process.

publication date

  • March 2016

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1097/MOG.0000000000000243

PubMed ID

  • 26760399

Additional Document Info

start page

  • 74

end page

  • 9

volume

  • 32

number

  • 2