Acquired resistance to immunotherapy and future challenges. Review uri icon

Overview

MeSH

  • Animals
  • Antibodies, Monoclonal
  • Antigens, CD274
  • Clinical Trials as Topic
  • Humans
  • Immunogenetic Phenomena
  • Melanoma
  • Mice
  • Selection, Genetic
  • T-Lymphocytes

MeSH Major

  • Immunotherapy
  • Neoplasms

abstract

  • Advances in immunotherapy have resulted in remarkable clinical responses in some patients. However, one of the biggest challenges in cancer therapeutics is the development of resistant disease and disease progression on or after therapy. Given that many patients have now received various types of immunotherapy, we asked three scientists to give their views on the current evidence for whether acquired resistance to immunotherapy exists in patients and the future challenges posed by immunotherapy.

publication date

  • February 2016

has subject area

  • Animals
  • Antibodies, Monoclonal
  • Antigens, CD274
  • Clinical Trials as Topic
  • Humans
  • Immunogenetic Phenomena
  • Immunotherapy
  • Melanoma
  • Mice
  • Neoplasms
  • Selection, Genetic
  • T-Lymphocytes

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1038/nrc.2016.2

PubMed ID

  • 26822578

Additional Document Info

start page

  • 121

end page

  • 126

volume

  • 16

number

  • 2