Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents Review uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Immunologic Factors
  • Neoplasms

abstract

  • The tremendous clinical success of checkpoint blockers illustrates the potential of reestablishing latent immunosurveillance for cancer therapy. Although largely neglected in the clinical practice, accumulating evidence indicates that the efficacy of conventional and targeted anticancer agents does not only involve direct cytostatic/cytotoxic effects, but also relies on the (re)activation of tumor-targeting immune responses. Chemotherapy can promote such responses by increasing the immunogenicity of malignant cells, or by inhibiting immunosuppressive circuitries that are established by developing neoplasms. These immunological "side" effects of chemotherapy are desirable, and their in-depth comprehension will facilitate the design of novel combinatorial regimens with improved clinical efficacy.

publication date

  • December 14, 2015

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.ccell.2015.10.012

PubMed ID

  • 26678337

Additional Document Info

start page

  • 690

end page

  • 714

volume

  • 28

number

  • 6