Cancer-treatment-induced neurotoxicity-focus on newer treatments Review uri icon


MeSH Major

  • Antineoplastic Agents
  • Drugs, Investigational
  • Neoplasms
  • Neurotoxicity Syndromes


  • Neurotoxicity caused by traditional chemotherapy and radiotherapy is widely recognized in patients with cancer. The adverse effects of newer therapeutics, such as biological and immunotherapeutic agents, are less well established, and are associated with considerable neurotoxicity in the central and peripheral nervous systems. This Review addresses the main neurotoxicities of cancer treatment with a focus on the newer therapeutics. Recognition of these patterns of toxicity is important because drug discontinuation or dose adjustment might prevent further neurological injury. Knowledge of these toxicities also helps to differentiate treatment-related symptoms from progression of cancer or its involvement of the nervous system. Familiarity with the neurological syndromes associated with cancer treatments enables clinicians to use the appropriate treatment for the underlying malignancy while minimizing the risk of neurological damage, which might preserve patients' quality of life.

publication date

  • February 2016



  • Review



  • eng

PubMed Central ID

  • PMC4979320

Digital Object Identifier (DOI)

  • 10.1038/nrclinonc.2015.152

PubMed ID

  • 26391778

Additional Document Info

start page

  • 92

end page

  • 105


  • 13


  • 2