Autophagy Mediates Tumor Suppression via Cellular Senescence Article uri icon

Overview

MeSH Major

  • Autophagy
  • Cell Aging

abstract

  • Autophagy not only constitutes a robust barrier against malignant transformation at the cell-intrinsic level, but also contributes to the organismal control of potentially oncogenic cells. Recent data provide molecular insights into the mechanisms whereby oncogene hyperactivation induces autophagy to establish a permanent proliferative arrest commonly known as cellular senescence.

publication date

  • January 2016

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.tcb.2015.11.001

Additional Document Info

start page

  • 1

end page

  • 3

volume

  • 26

number

  • 1