Opposing roles for serotonin in cholinergic neurons of the ventral and dorsal striatum Academic Article uri icon


MeSH Major

  • Cholinergic Neurons
  • Neostriatum
  • Serotonin


  • Little is known about the molecular similarities and differences between neurons in the ventral (vSt) and dorsal striatum (dSt) and their physiological implications. In the vSt, serotonin [5-Hydroxytryptamine (5-HT)] modulates mood control and pleasure response, whereas in the dSt, 5-HT regulates motor behavior. Here we show that, in mice, 5-HT depolarizes cholinergic interneurons (ChIs) of the dSt whereas hyperpolarizing ChIs from the vSt by acting on different 5-HT receptor isoforms. In the vSt, 5-HT1A (a postsynaptic receptor) and 5-HT1B (a presynaptic receptor) are highly expressed, and synergistically inhibit the excitability of ChIs. The inhibitory modulation by 5-HT1B, but not that by 5-HT1A, is mediated by p11, a protein associated with major depressive disorder. Specific deletion of 5-HT1B from cholinergic neurons results in impaired inhibition of ACh release in the vSt and in anhedonic-like behavior.

publication date

  • January 19, 2016



  • Academic Article



  • eng

PubMed Central ID

  • PMC4725497

Digital Object Identifier (DOI)

  • 10.1073/pnas.1524183113

PubMed ID

  • 26733685

Additional Document Info

start page

  • 734

end page

  • 9


  • 113


  • 3