Angiocrine functions of organ-specific endothelial cells. Review uri icon

Overview

MeSH

  • Animals
  • Capillaries
  • Cell Differentiation
  • Cell Self Renewal
  • Homeostasis
  • Humans
  • Liver Cirrhosis
  • Lung
  • Organ Specificity
  • Osteogenesis
  • Regeneration

MeSH Major

  • Endothelial Cells
  • Neovascularization, Physiologic
  • Paracrine Communication

abstract

  • Endothelial cells that line capillaries are not just passive conduits for delivering blood. Tissue-specific endothelium establishes specialized vascular niches that deploy sets of growth factors, known as angiocrine factors. These cues participate actively in the induction, specification, patterning and guidance of organ regeneration, as well as in the maintainance of homeostasis and metabolism. When upregulated following injury, they orchestrate self-renewal and differentiation of tissue-specific resident stem and progenitor cells into functional organs. Uncovering the mechanisms by which organotypic endothelium distributes physiological levels of angiocrine factors both spatially and temporally will lay the foundation for clinical trials that promote organ repair without scarring.

publication date

  • January 21, 2016

has subject area

  • Animals
  • Capillaries
  • Cell Differentiation
  • Cell Self Renewal
  • Endothelial Cells
  • Homeostasis
  • Humans
  • Liver Cirrhosis
  • Lung
  • Neovascularization, Physiologic
  • Organ Specificity
  • Osteogenesis
  • Paracrine Communication
  • Regeneration

Research

keywords

  • Journal Article
  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC4878406

Digital Object Identifier (DOI)

  • 10.1038/nature17040

PubMed ID

  • 26791722

Additional Document Info

start page

  • 316

end page

  • 325

volume

  • 529

number

  • 7586