The miR-17-92 cluster counteracts quiescence and chemoresistance in a distinct subpopulation of pancreatic cancer stem cells Academic Article uri icon

Overview

MeSH Major

  • Antimetabolites, Antineoplastic
  • Carcinoma, Pancreatic Ductal
  • Deoxycytidine
  • Drug Resistance, Neoplasm
  • MicroRNAs
  • Neoplastic Stem Cells
  • Pancreatic Neoplasms

abstract

  • Our findings therefore identify the miR-17-92 cluster as a functionally determining family of miRNAs in CSCs, and highlight the putative potential of developing modulators of this cluster to overcome drug resistance in pancreatic CSCs.

publication date

  • December 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4680182

Digital Object Identifier (DOI)

  • 10.1136/gutjnl-2014-308470

PubMed ID

  • 25887381

Additional Document Info

start page

  • 1936

end page

  • 48

volume

  • 64

number

  • 12