Leveraging Optogenetic-Based Neurovascular Circuit Characterization for Repair Review uri icon

Overview

MeSH Major

  • Nervous System Diseases
  • Neural Pathways
  • Optogenetics

abstract

  • Optogenetic techniques are a powerful tool for determining the role of individual functional components within complex neural circuits. By genetically targeting specific cell types, neural mechanisms can be actively manipulated to gain a better understanding of their origin and function, both in health and disease. The potential of optogenetics is not limited to answering biological questions, as it is also a promising therapeutic approach for neurological diseases. An important prerequisite for this approach is to have an identified target with a uniquely defined role within a given neural circuit. Here, we examine the retinal neurovascular unit, a circuit that incorporates neurons and vascular cells to control blood flow in the retina. We highlight the role of a specific cell type, the cholinergic amacrine cell, in modulating vascular cells, and demonstrate how this can be targeted and controlled with optogenetics. A better understanding of these mechanisms will not only extend our understanding of neurovascular interactions in the brain, but ultimately may also provide new targets to treat vision loss in a variety of retinal diseases.

publication date

  • January 12, 2016

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC4824015

Digital Object Identifier (DOI)

  • 10.1007/s13311-015-0419-x

PubMed ID

  • 26758692

Additional Document Info