Expression Levels of DNA Damage Repair Proteins Are Associated With Overall Survival in Platinum-Treated Advanced Urothelial Carcinoma Academic Article uri icon

Overview

MeSH Major

  • Carcinoma, Transitional Cell
  • DNA-Binding Proteins
  • Endonucleases
  • Fanconi Anemia Complementation Group Proteins
  • Membrane Proteins
  • Neoplasm Proteins
  • Platinum
  • Poly (ADP-Ribose) Polymerase-1
  • Urologic Neoplasms

abstract

  • A high percentage of nuclear staining of ERCC1, RAD51, and PAR, assessed by immunohistochemistry, correlated with worse OS for patients with mUC treated with first-line platinum combination chemotherapy, supporting the evidence of the DNA repair pathways' role in the prognosis of mUC. We also report new evidence that RAD51 and PAR might play a role in the platinum response. Additional prospective studies are required to determine the prognostic or predictive nature of these biomarkers in mUC.

publication date

  • August 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5508512

Digital Object Identifier (DOI)

  • 10.1016/j.clgc.2015.12.029

PubMed ID

  • 26778300

Additional Document Info

start page

  • 352

end page

  • 9

volume

  • 14

number

  • 4