Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma Academic Article uri icon

Overview

MeSH Major

  • Carcinoma, Papillary
  • Kidney Neoplasms
  • Mutation
  • NF-E2-Related Factor 2
  • Proto-Oncogene Proteins c-met

abstract

  • Type 1 and type 2 papillary renal-cell carcinomas were shown to be clinically and biologically distinct. Alterations in the MET pathway were associated with type 1, and activation of the NRF2-ARE pathway was associated with type 2; CDKN2A loss and CIMP in type 2 conveyed a poor prognosis. Furthermore, type 2 papillary renal-cell carcinoma consisted of at least three subtypes based on molecular and phenotypic features. (Funded by the National Institutes of Health.).

authors

publication date

  • January 14, 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4775252

Digital Object Identifier (DOI)

  • 10.1056/NEJMoa1505917

PubMed ID

  • 26536169

Additional Document Info

start page

  • 135

end page

  • 45

volume

  • 374

number

  • 2