TRAIL-coated leukocytes that prevent the bloodborne metastasis of prostate cancer Academic Article uri icon

Overview

MeSH Major

  • E-Selectin
  • Leukocytes
  • Neoplastic Cells, Circulating
  • Prostatic Neoplasms
  • TNF-Related Apoptosis-Inducing Ligand

abstract

  • Prostate cancer, once it has progressed from its local to metastatic form, is a disease with poor prognosis and limited treatment options. Here we demonstrate an approach using nanoscale liposomes conjugated with E-selectin adhesion protein and Apo2L/TRAIL (TNF-related apoptosis-inducing ligand) apoptosis ligand that attach to the surface of leukocytes and rapidly clear viable cancer cells from circulating blood in the living mouse. For the first time, it is shown that such an approach can be used to prevent the spontaneous formation and growth of metastatic tumors in an orthotopic xenograft model of prostate cancer, by greatly reducing the number of circulating tumor cells. We conclude that the use of circulating leukocytes as a carrier for the anti-cancer protein TRAIL could be an effective tool to directly target circulating tumor cells for the prevention of prostate cancer metastasis, and potentially other cancers that spread through the bloodstream.

publication date

  • February 10, 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4724502

Digital Object Identifier (DOI)

  • 10.1016/j.jconrel.2015.12.048

PubMed ID

  • 26732555

Additional Document Info

start page

  • 215

end page

  • 23

volume

  • 223