Serum biomarkers associated with clinical outcomes fail to predict brain metastases in patients with stage IV non-small cell lung cancers Academic Article uri icon

Overview

MeSH Major

  • Biomarkers, Tumor
  • Brain Neoplasms
  • Carcinoma, Non-Small-Cell Lung
  • Lung Neoplasms

abstract

  • Serum NSE, CYFRA 21-1, Pro-GRP, SCC-Ag, TIMP1, and HE4 are not significantly associated with brain metastases. Our methods taking into account follow-up time may be applied to independent datasets to identify a patient cohort with a higher biologic propensity for developing brain metastases. Such information may be useful for the study of agents targeting the development of brain metastases.

publication date

  • January 5, 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4701719

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0146063

PubMed ID

  • 26730601

Additional Document Info

start page

  • e0146063

volume

  • 11

number

  • 1