Transcriptional Profiling Identifies the Signaling Axes of IGF and Transforming Growth Factor-β as Involved in the Pathogenesis of Osteosarcoma Academic Article uri icon


MeSH Major

  • Biomarkers, Tumor
  • Bone Neoplasms
  • Gene Expression Profiling
  • Osteosarcoma
  • Signal Transduction
  • Somatomedins
  • Transforming Growth Factor beta


  • Based on these transcriptional profiles, a coordinated theme of clustered gene deregulation in osteosarcoma has emerged. Cell proliferation driven by the IGF axes during bone growth is unrestrained owing to downregulation of IGFBPs and cell cycle regulators. Tumor cells may be maintained in an undifferentiated state secondary to impaired TGF-b/BMP signaling. This wellpreserved pattern suggests that the alterations in the signaling axes of IGF-1 and TGF-b, in concert with cell cycle regulators, may be an important pathogenic basis of osteosarcoma. CLINIC RELEVANCE: This study provides a possible molecular basis of pathogenesis of osteosarcoma. This may help to develop new therapeutic targets and strategy for this disease. Preclinical and subsequently clinical testing of inhibitors of the IGF-1 and TGF pathways would be warranted.

publication date

  • January 2016



  • Academic Article



  • eng

PubMed Central ID

  • PMC4686509

Digital Object Identifier (DOI)

  • 10.1007/s11999-015-4578-1

PubMed ID

  • 26463566

Additional Document Info

start page

  • 178

end page

  • 89


  • 474


  • 1