Facilitated long chain fatty acid uptake by adipocytes remains upregulated relative to BMI for more than a year after major bariatric surgical weight loss. Academic Article uri icon

Overview

MeSH

  • Adult
  • Female
  • Follow-Up Studies
  • Gastrectomy
  • Humans
  • Male
  • Middle Aged
  • Omentum
  • Subcutaneous Fat
  • Up-Regulation

MeSH Major

  • Adipocytes
  • Bariatric Surgery
  • Body Mass Index
  • Fatty Acids
  • Obesity
  • Weight Loss

abstract

  • This study examined whether changes in adipocyte long chain fatty acid (LCFA) uptake kinetics explain the weight regain increasingly observed following bariatric surgery. Three groups (10 patients each) were studied: patients without obesity (NO: BMI 24.2 ± 2.3 kg m(-2) ); patients with obesity (O: BMI 49.8 ± 11.9); and patients classified as super-obese (SO: BMI 62.6 ± 2.8). NO patients underwent omental and subcutaneous fat biopsies during clinically indicated abdominal surgeries; O were biopsied during bariatric surgery, and SO during both a sleeve gastrectomy and at another bariatric operation 16 ± 2 months later, after losing 113 ± 13 lbs. Adipocyte sizes and [(3) H]-LCFA uptake kinetics were determined in all biopsies. Vmax for facilitated LCFA uptake by omental adipocytes increased exponentially from 5.1 ± 0.95 to 21.3 ± 3.20 to 68.7 ± 9.45 pmol/sec/50,000 cells in NO, O, and SO patients, respectively, correlating with BMI (r = 0.99, P < 0.001). Subcutaneous results were virtually identical. By the second operation, the mean BMI (SO patients) fell significantly (P < 0.01) to 44.4 ± 2.4 kg m(-2) , similar to the O group. However, Vmax (40.6 ± 11.5) in this weight-reduced group remained ~2X that predicted from the BMI:Vmax regression among NO, O, and SO patients. Facilitated adipocyte LCFA uptake remains significantly upregulated ≥1 year after bariatric surgery, possibly contributing to weight regain. © 2015 The Obesity Society.

publication date

  • January 2016

has subject area

  • Adipocytes
  • Adult
  • Bariatric Surgery
  • Body Mass Index
  • Fatty Acids
  • Female
  • Follow-Up Studies
  • Gastrectomy
  • Humans
  • Male
  • Middle Aged
  • Obesity
  • Omentum
  • Subcutaneous Fat
  • Up-Regulation
  • Weight Loss

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4699588

Digital Object Identifier (DOI)

  • 10.1002/oby.21249

PubMed ID

  • 26584686

Additional Document Info

start page

  • 113

end page

  • 122

volume

  • 24

number

  • 1