Treatment of small-cell lung cancer: American society of clinical oncology endorsement of the American college of chest physicians guideline Academic Article uri icon


MeSH Major

  • Lung Neoplasms
  • Practice Guidelines as Topic
  • Small Cell Lung Carcinoma


  • Surgery is indicated for selected stage I SCLC. Limited-stage disease should be treated with concurrent chemoradiotherapy in patients with good performance status. Thoracic radiotherapy should be administered early in the course of treatment, preferably beginning with cycle one or two of chemotherapy. Chemotherapy should consist of four cycles of a platinum agent and etoposide. Extensive-stage disease should be treated primarily with chemotherapy consisting of a platinum agent plus etoposide or irinotecan. Prophylactic cranial irradiation prolongs survival in patients with limited-stage disease who achieve a complete or partial response to initial therapy and may do so in similarly responding patients with extensive-stage disease as well. Additional information is available at and

publication date

  • December 2015



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.2015.63.7918

PubMed ID

  • 26351333

Additional Document Info

start page

  • 4106

end page

  • 11


  • 33


  • 34