The Potential of High Resolution Magnetic Resonance Microscopy in the Pathologic Analysis of Resected Breast and Lymph Tissue. Academic Article uri icon

Overview

MeSH

  • Diagnostic Imaging
  • Female
  • Humans
  • Lymph Nodes
  • Magnetic Resonance Imaging
  • Surveys and Questionnaires

MeSH Major

  • Breast
  • Magnetic Resonance Spectroscopy
  • Microscopy

abstract

  • Pathologic evaluation of breast specimens requires a fixation and staining procedure of at least 12 hours duration, delaying diagnosis and post-operative planning. Here we introduce an MRI technique with a custom-designed radiofrequency resonator for imaging breast and lymph tissue with sufficient spatial resolution and speed to guide pathologic interpretation and offer value in clinical decision making. In this study, we demonstrate the ability to image breast and lymphatic tissue using 7.0 Tesla MRI, achieving a spatial resolution of 59 × 59 × 94 μm(3) with a signal-to-noise ratio of 15-20, in an imaging time of 56 to 70 minutes. These are the first MR images to reveal characteristic pathologic features of both benign and malignant breast and lymph tissue, some of which were discernible by blinded pathologists who had no prior training in high resolution MRI interpretation.

publication date

  • December 7, 2015

has subject area

  • Breast
  • Diagnostic Imaging
  • Female
  • Humans
  • Lymph Nodes
  • Magnetic Resonance Imaging
  • Magnetic Resonance Spectroscopy
  • Microscopy
  • Surveys and Questionnaires

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4671009

Digital Object Identifier (DOI)

  • 10.1038/srep17435

PubMed ID

  • 26639673

Additional Document Info

start page

  • 17435

volume

  • 5