Identification of germline genetic mutations in patients with pancreatic cancer Academic Article uri icon

Overview

MeSH Major

  • Adenocarcinoma
  • DNA Mismatch Repair
  • Genes, BRCA1
  • Genes, BRCA2
  • Genes, p16
  • Germ-Line Mutation
  • Nuclear Proteins
  • Pancreatic Neoplasms
  • Tumor Suppressor Proteins

abstract

  • Mutations in BRCA2 account for > 50% of patients with PAC with an identified susceptibility syndrome. AJ patients were found to have high BRCA1/BRCA2 prevalence regardless of personal/family history, suggesting that ancestry alone indicates a need for genetic evaluation. With the exception of BRCA2-associated PAC, an inherited predisposition for PAC is associated with an earlier age at PAC diagnosis, suggesting that this subset of patients may also represent a population warranting further evaluation. Cancer 2015;121:4382-8. © 2015 American Cancer Society.

publication date

  • December 15, 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5193099

Digital Object Identifier (DOI)

  • 10.1002/cncr.29664

PubMed ID

  • 26440929

Additional Document Info

start page

  • 4382

end page

  • 8

volume

  • 121

number

  • 24