Validation and genomic interrogation of the MET variant rs11762213 as a predictor of adverse outcomes in clear cell renal cell carcinoma Academic Article uri icon

Overview

MeSH Major

  • Carcinoma, Renal Cell
  • Kidney Neoplasms
  • Polymorphism, Single Nucleotide
  • Proto-Oncogene Proteins c-met

abstract

  • The exonic MET variant rs11762213 is an independent predictor of adverse CSS and TTR in ccRCC and should be integrated into clinical practice for prognostic stratification. Genomic analysis suggests that the single-nucleotide polymorphism may affect an enhancer region located in the coding region of MET. Further biological mechanistic interrogation is currently underway.

publication date

  • February 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4803437

Digital Object Identifier (DOI)

  • 10.1002/cncr.29765

PubMed ID

  • 26505625

Additional Document Info

start page

  • 402

end page

  • 10

volume

  • 122

number

  • 3