The quest for spatio-temporal control of CAR T cells Comment uri icon

Overview

MeSH Major

  • Neoplasms
  • Receptors, Antigen, T-Cell
  • Small Molecule Libraries
  • T-Lymphocytes

abstract

  • Chimeric antigen receptors (CARs) are synthetic receptors capable of directing potent antigen-specific anti-tumor T cell responses. A recent report by Wu et al. extends a series of strategies aiming to curb excessive T cell activity, utilizing in this instance a chemical dimerizer to aggregate antigen-binding, T cell-activating and costimulatory domains.

publication date

  • December 2015

Research

keywords

  • Comment

Identity

Digital Object Identifier (DOI)

  • 10.1038/cr.2015.131

PubMed ID

  • 26575974

Additional Document Info

start page

  • 1281

end page

  • 2

volume

  • 25

number

  • 12