Optimizing treatments for anxiety by age and genetics Review uri icon

Overview

MeSH Major

  • Anxiety
  • Anxiety Disorders
  • Precision Medicine

abstract

  • This paper highlights recent human neuroimaging and cross-species developmental and genetic studies that examine how fear regulation varies by age and the individual, especially during the period of adolescence, when there is a peak in the prevalence of anxiety disorders. The findings have significant implications for understanding who may be at risk for anxiety disorders and for whom, and when, an exposure-based therapy may be most effective. We provide proof of concept for targeting treatment to the individual as a function of age and genetics, inferred from mouse and human studies, and suggest optimization of treatment for nonresponders.

publication date

  • January 2015

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC4447548

Digital Object Identifier (DOI)

  • 10.1111/nyas.12746

PubMed ID

  • 25801102

Additional Document Info

start page

  • 16

end page

  • 24

volume

  • 1345

number

  • 1