Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs Academic Article uri icon


MeSH Major

  • Immunity, Innate
  • Lymphocytes
  • Lymphoid Tissue


  • Innate lymphoid cells (ILCs) contribute to barrier immunity, tissue homeostasis, and immune regulation at various anatomical sites throughout the body. How ILCs maintain their presence in lymphoid and peripheral tissues thus far has been unclear. We found that in the lymphoid and nonlymphoid organs of adult mice, ILCs are tissue-resident cells that were maintained and expanded locally under physiologic conditions, upon systemic perturbation of immune homeostasis and during acute helminth infection. However, at later time points after infection, cells from hematogenous sources helped to partially replenish the pool of resident ILCs. Thus, ILCs are maintained by self-renewal in broadly different microenvironments and physiological settings. Such an extreme "sedentary" lifestyle is consistent with the proposed roles of ILCs as sentinels and local keepers of tissue function.

publication date

  • November 20, 2015



  • Academic Article



  • eng

PubMed Central ID

  • PMC4720139

Digital Object Identifier (DOI)

  • 10.1126/science.aac9593

PubMed ID

  • 26472762

Additional Document Info

start page

  • 981

end page

  • 5


  • 350


  • 6263