Cancer's Fuel Choice: New Flavors for a Picky Eater Review uri icon

Overview

MeSH Major

  • Neoplasms
  • Oxygen

abstract

  • Otto Warburg discovered that cancer cells exhibit a high rate of glycolysis in the presence of ample oxygen, a process termed aerobic glycolysis, in 1924 (Warburg et al., 1924). Since then we have significantly advanced our understanding of cancers' fuel choice to meet their demands for energy and for the production of biosynthetic precursors. In this review, we will discuss the preferred nutrients of cancer cells and how they are utilized to satisfy their bioenergetic and biosynthetic needs. In addition, we will describe how cell intrinsic and extrinsic factors such as oncogene mutations, nutrient and oxygen availability, and other microenvironmental factors influence fuel choice.

publication date

  • January 2015

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC4676726

Digital Object Identifier (DOI)

  • 10.1016/j.molcel.2015.10.018

PubMed ID

  • 26590711

Additional Document Info

start page

  • 514

end page

  • 23

volume

  • 60

number

  • 4