Long-term follow up of rates of secondary malignancy and late relapse of two trials using radioimmunotherapy consolidation following induction chemotherapy for previously untreated indolent lymphoma. Academic Article uri icon

Overview

MeSH

  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Combined Chemotherapy Protocols
  • Biopsy
  • Bone Marrow
  • Clinical Trials, Phase II as Topic
  • Clinical Trials, Phase III as Topic
  • Consolidation Chemotherapy
  • Female
  • Follow-Up Studies
  • Humans
  • Induction Chemotherapy
  • Kaplan-Meier Estimate
  • Leukemia, Myeloid, Acute
  • Male
  • Middle Aged
  • Myelodysplastic Syndromes
  • Recurrence
  • Tomography, X-Ray Computed
  • Treatment Outcome

MeSH Major

  • Lymphoma
  • Neoplasms, Second Primary
  • Radioimmunotherapy

abstract

  • Existing data suggest that myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) peak in incidence 5-10 years following exposure to ionizing radiation, while most publications report less than 5 years of follow-up after radioimmunotherapy (RIT). We report the rate of secondary MDS/AML among 60 patients treated with two front-line sequential chemotherapy-RIT trials with over 11 years of follow-up. Among 35 patients evaluated after fludarabine-RIT and 25 patients evaluated after CVP (cyclophosphamide, vincristine, prednisone)-RIT treatment, the crude, cumulative and Kaplan-Meier rates of MDS/AML at 11 years of follow-up from the combined trials were 0.12/person, 0.010/person-year and 14% (95% confidence interval [CI] 5-24%), respectively. Additionally, we found that patients treated with RIT consolidation appear to have durable remissions but that relapses after 10 years do occur. Studies of efficacy and secondary MDS/AML that report fewer than 10 years of follow-up likely underestimate risk.

publication date

  • 2015

has subject area

  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Combined Chemotherapy Protocols
  • Biopsy
  • Bone Marrow
  • Clinical Trials, Phase II as Topic
  • Clinical Trials, Phase III as Topic
  • Consolidation Chemotherapy
  • Female
  • Follow-Up Studies
  • Humans
  • Induction Chemotherapy
  • Kaplan-Meier Estimate
  • Leukemia, Myeloid, Acute
  • Lymphoma
  • Male
  • Middle Aged
  • Myelodysplastic Syndromes
  • Neoplasms, Second Primary
  • Radioimmunotherapy
  • Recurrence
  • Tomography, X-Ray Computed
  • Treatment Outcome

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.3109/10428194.2015.1016929

PubMed ID

  • 25676037

Additional Document Info

start page

  • 2870

end page

  • 2875

volume

  • 56

number

  • 10