Treatment of metastatic cutaneous crohn disease with certolizumab Academic Article Article uri icon

Overview

MeSH Major

  • Pyrimidines
  • Scleroderma, Diffuse
  • Skin
  • Transcriptome

abstract

  • © 2015 by the article author(s). Metastatic Crohn disease is a rare cutaneous manifestation of Crohn disease characterized by granulomatous lesions discontinuous with the diseased areas of the gastrointestinal tract. We report a case of a 32-year-old woman with history of Crohn disease who was admitted for treatment of cellulitis after presenting with a tender erythematous plaque of the left calf. Microbiological tests including tissue cultures were negative. A skin biopsy revealed granulomatous dermatitis consistent with metastatic cutaneous Crohn disease. Owing to concomitant perianal fistulas and abscesses and prior infusion reaction to infliximab, the patient was treated with certolizumab, a pegylated tumor necrosis factor (TNF) inhibitor combined with methotrexate resulting in complete resolution of the skin lesion. This case emphasizes the importance of recognizing this rare skin manifestation of Crohn disease and adds certolizumab as one of TNF inhibitors useful in the treatment of metastatic cutaneous Crohn disease.

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

PubMed ID

  • 26632928

Additional Document Info

volume

  • 21

number

  • 11