Functional regulation of FoxO1 in neural stem cell differentiation Academic Article uri icon

Overview

MeSH Major

  • Forkhead Transcription Factors

abstract

  • Forkhead transcription factor family O (FoxO) maintains adult stem cell reserves by supporting their long-term proliferative potential. MicroRNAs (miRs) regulate neuronal stem/progenitor cell (NSPC) proliferation and differentiation during neural development by controlling the expression of a specific set of target genes. In the neurogenic subventricular zone, FoxO1 is specifically expressed in NSPCs and is no longer detected during the transition to neuroblast stage, forming an inverse correlation with miR-9 expression. The 3'-untranslated region of FoxO1 contains a conserved target sequence of miR-9 and FoxO1 expression is coordinated in concert with miR-9 during neuronal differentiation. Our study demonstrates that FoxO1 contributes to NSPC fate decision through its cooperation with the Notch signaling pathway.

publication date

  • December 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4816100

Digital Object Identifier (DOI)

  • 10.1038/cdd.2015.123

PubMed ID

  • 26470727

Additional Document Info

start page

  • 2034

end page

  • 45

volume

  • 22

number

  • 12