Daidzein augments cholesterol homeostasis via apoE to promote functional recovery in chronic stroke Academic Article uri icon


MeSH Major

  • Apolipoproteins E
  • Cholesterol
  • Homeostasis
  • Isoflavones
  • Recovery of Function
  • Stroke


  • There have been recurring translational failures in treatment strategies for stroke. One underlying issue is the disparity in outcome analysis between animal and clinical studies. The former mainly depends on acute infarct size, whereas long-term functional recovery is an important outcome in patients. In an attempt to identify agents that promote functional recovery, we discovered that an FDA-approved soy isoflavone, daidzein, improved stroke-induced behavioral deficits via enhancing cholesterol homeostasis in chronic stroke, and this occurs without causing adverse effects in the acute phase. With its known safety in humans, the study suggests that the early and chronic use of daidzein serves as a potential strategy to promote functional recovery in stroke patients.

publication date

  • January 2015



  • Academic Article



  • eng

PubMed Central ID

  • PMC4642242

Digital Object Identifier (DOI)

  • 10.1523/JNEUROSCI.2890-15.2015

PubMed ID

  • 26558782

Additional Document Info

start page

  • 15113

end page

  • 26


  • 35


  • 45