Feasibility and Domain Validation of Rheumatoid Arthritis (RA) Flare Core Domain Set: Report of the OMERACT 2014 RA Flare Group Plenary. Academic Article Review uri icon

Overview

MeSH

  • Feasibility Studies
  • Female
  • Humans
  • Male
  • Observational Studies as Topic
  • Quebec
  • Randomized Controlled Trials as Topic

MeSH Major

  • Arthritis, Rheumatoid
  • Consensus Development Conferences as Topic
  • Disease Progression
  • Outcome Assessment (Health Care)
  • Pain Measurement

abstract

  • The Outcome Measures in Rheumatology (OMERACT) Rheumatoid Arthritis (RA) Flare Group was established to develop an approach to identify and measure RA flares. An overview of our OMERACT 2014 plenary is provided. Feasibility and validity of flare domains endorsed at OMERACT 11 (2012) were described based on initial data from 3 international studies collected using a common set of questions specific to RA flare. Mean flare frequency, severity, and duration data were presented, and domain scores were compared by flare status to examine known-groups validity. Breakout groups provided input for stiffness, self-management, contextual factors, and measurement considerations. Flare data from 501 patients in an observational study indicated 39% were in flare, with mean (SD) severity of 6.0 (2.6) and 55% lasting > 14 days. Pain, physical function, fatigue, participation, and stiffness scores averaged ≥ 2 times higher (2 of 11 points) in flaring individuals. Correlations between flare domains and corresponding legacy instruments were obtained: r = 0.46 to 0.93. A combined definition (patient report of flare and 28-joint Disease Activity Score increase) was evaluated in 2 other trials, with similar results. Breakout groups debated specific measurement issues. These data contribute initial evidence of feasibility and content validation of the OMERACT RA Flare Core Domain Set. Our research agenda for OMERACT 2016 includes establishing duration/intensity criteria and developing criteria to identify RA flares using existing disease activity measures. Ongoing work will also address discordance between patient and physician ratings, facilitate application of flare criteria to clinical care, elucidate the role of self-management, and finalize recommendations for RA flare measurement.

publication date

  • November 2015

has subject area

  • Arthritis, Rheumatoid
  • Consensus Development Conferences as Topic
  • Disease Progression
  • Feasibility Studies
  • Female
  • Humans
  • Male
  • Observational Studies as Topic
  • Outcome Assessment (Health Care)
  • Pain Measurement
  • Quebec
  • Randomized Controlled Trials as Topic

Research

keywords

  • Journal Article
  • Review
  • Validation Studies

Identity

Language

  • eng

PubMed Central ID

  • PMC4747421

Digital Object Identifier (DOI)

  • 10.3899/jrheum.141169

PubMed ID

  • 25684764

Additional Document Info

start page

  • 2185

end page

  • 2189

volume

  • 42

number

  • 11