Changes in the amino acid sequence of the recombinant human factor VIIa analog, vatreptacog alfa, are associated with clinical immunogenicity Academic Article uri icon

Overview

MeSH Major

  • Amino Acid Substitution
  • Factor VIIa
  • Isoantibodies

abstract

  • Results from the vatreptacog alfa phase III trial demonstrate that the specific changes made, albeit relatively small, to the FVIIa molecule alter its clinical immunogenicity.

authors

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1111/jth.13141

PubMed ID

  • 26362483

Additional Document Info

start page

  • 1989

end page

  • 98

volume

  • 13

number

  • 11