Ptdins(3,4,5) P3 -dependent activation of the mTORC2 kinase complex Academic Article uri icon

Overview

MeSH Major

  • Multiprotein Complexes
  • Phosphatidylinositol Phosphates
  • TOR Serine-Threonine Kinases

abstract

  • The SIN1-PH domain interacts with the mTOR kinase domain to suppress mTOR activity, and PtdIns(3,4,5)P3 binds the SIN1-PH domain to release its inhibition on the mTOR kinase domain, leading to mTORC2 activation. Cancer patient-derived SIN1-PH domain mutations gain oncogenicity by loss of suppressing mTOR activity as a means to facilitate tumorigenesis. Cancer Discov; 5(11); 1194-209. ©2015 AACR.See related commentary by Yuan and Guan, p. 1127.This article is highlighted in the In This Issue feature, p. 1111.

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4631654

Digital Object Identifier (DOI)

  • 10.1158/2159-8290.CD-15-0460

PubMed ID

  • 26293922

Additional Document Info

start page

  • 1194

end page

  • 209

volume

  • 5

number

  • 11