Exome Sequencing Analysis Reveals Variants in Primary Immunodeficiency Genes in Patients with Very Early Onset Inflammatory Bowel Disease Academic Article uri icon

Overview

MeSH Major

  • Aging
  • Exome
  • Immunologic Deficiency Syndromes
  • Inflammatory Bowel Diseases
  • Mutation

abstract

  • In an exome sequence analysis of patients with VEO-IBD and their parents, we identified variants in genes that regulate B- and T-cell functions and could contribute to pathogenesis. Our analysis could lead to the identification of previously unidentified IBD-associated variants.

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4853027

Digital Object Identifier (DOI)

  • 10.1053/j.gastro.2015.07.006

PubMed ID

  • 26193622

Additional Document Info

start page

  • 1415

end page

  • 24

volume

  • 149

number

  • 6