APOE-by-sex interactions on brain structure and metabolism in healthy elderly controls Academic Article uri icon

Overview

MeSH Major

  • Apolipoprotein E4
  • Biomarkers
  • Sex Factors

abstract

  • The impact of APOE4 on brain metabolism and structure is modified by sex. Female APOE4 carriers show greater hypometabolism and atrophy than male carriers. This APOE-by-sex interaction should be considered in clinical trials in preclinical AD where APOE4 status is a selection criterion.

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4694943

Digital Object Identifier (DOI)

  • 10.18632/oncotarget.5185

PubMed ID

  • 26397226

Additional Document Info

start page

  • 26663

end page

  • 74

volume

  • 6

number

  • 29