Combinatorial immunotherapy with checkpoint blockers solves the problem of metastatic melanoma— An exclamation sign with a question mark Academic Article uri icon


MeSH Major

  • HSP70 Heat-Shock Proteins
  • Neoplasms


  • Results from recent clinical trials demonstrate that a combinatorial immunotherapeutic regimen based on 2 distinct checkpoint blockers, namely, the CTLA4-targeting agent ipilimumab and the PD-1-specific molecule nivolumab, causes objective responses in a majority of subjects with advanced melanoma. These findings revolutionize the treatment of a neoplasm that was considered incurable until recently. Nonetheless, announcing the defeat of melanoma appears premature. Indeed, a sizeable fraction of patients does not respond to ipilimumab plus nivolumab, and the long-term efficacy of this immunotherapeutic regimen has not yet been investigated. Moreover, many patients experience severe side effects, calling for the development of strategies that uncouple the efficacy of ipilimumab plus nivolumab from their toxicity.

publication date

  • January 2015



  • Academic Article



  • eng

PubMed Central ID

  • PMC4485790

Digital Object Identifier (DOI)

  • 10.1080/2162402X.2015.1058037

PubMed ID

  • 26140249

Additional Document Info

start page

  • e1058037


  • 4


  • 7