Absence of canonical marks of active chromatin in developmentally regulated genes Academic Article uri icon

Overview

MeSH Major

  • Chromatin
  • Gene Expression Regulation, Developmental

abstract

  • The interplay of active and repressive histone modifications is assumed to have a key role in the regulation of gene expression. In contrast to this generally accepted view, we show that the transcription of genes temporally regulated during fly and worm development occurs in the absence of canonically active histone modifications. Conversely, strong chromatin marking is related to transcriptional and post-transcriptional stability, an association that we also observe in mammals. Our results support a model in which chromatin marking is associated with the stable production of RNA, whereas unmarked chromatin would permit rapid gene activation and deactivation during development. In the latter case, regulation by transcription factors would have a comparatively more important regulatory role than chromatin marks.

publication date

  • September 29, 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4625605

Digital Object Identifier (DOI)

  • 10.1038/ng.3381

PubMed ID

  • 26280901

Additional Document Info

start page

  • 1158

end page

  • 1167

volume

  • 47

number

  • 10