Non-16/18 high-risk HPV infection predicts disease persistence and progression in women with an initial interpretation of LSIL
Carcinoma, Squamous Cell
Cervical Intraepithelial Neoplasia
Infection with non-16/18 HR-HPV genotypes but not with HPV-16/18 genotypes was a strong predictor of the persistence and progression of cervical disease upon follow-up. Genotyping solely for HPV-16/18 would miss the majority of patients with LSIL who progress to high-grade squamous intraepithelial lesions. Pooled HR-HPV tests provide a better predictive value than HPV-16/18 genotyping alone in guiding the clinical management of patients with LSIL.