AKT1 E17K in colorectal carcinoma is associated with BRAF V600E but not MSI-H status: A clinicopathologic comparison to PIK3CA helical and kinase domain mutants Academic Article uri icon

Overview

MeSH Major

  • Colorectal Neoplasms
  • Microsatellite Instability
  • Mutation
  • Phosphatidylinositol 3-Kinases
  • Proto-Oncogene Proteins B-raf
  • Proto-Oncogene Proteins c-akt

abstract

  • This first systematic study of AKT1 and PIK3CA hotspot mutations and their association with cetuximab resistance and BRAF V600E mutation has important ramifications for the development of personalized medicine, particularly in identifying patient candidates for PI3K or AKT inhibitors.

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4978128

Digital Object Identifier (DOI)

  • 10.1158/1541-7786.MCR-15-0062-T

PubMed ID

  • 25714871

Additional Document Info

start page

  • 1003

end page

  • 8

volume

  • 13

number

  • 6