Monocyte-derived dendritic cells upregulate extracellular catabolism of aggregated low-density lipoprotein on maturation, leading to foam cell formation Academic Article uri icon

Overview

MeSH Major

  • Atherosclerosis
  • Dendritic Cells
  • Foam Cells
  • Lipoproteins, LDL
  • Phagocytosis

abstract

  • Our results show that monocyte-derived dendritic cells use exophagy to degrade aggregated LDL and become foam cells, whereas monocyte-independent dendritic cells are unable to clear LDL deposits. Furthermore, we find that exophagy is upregulated on dendritic cell maturation. Thus, exophagy-mediated foam cell formation in monocyte-derived dendritic cells could play a significant role in atherogenesis.

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4583358

Digital Object Identifier (DOI)

  • 10.1161/ATVBAHA.115.305843

PubMed ID

  • 26293468

Additional Document Info

start page

  • 2092

end page

  • 103

volume

  • 35

number

  • 10