Anomalous Glucose and Insulin Responses in Patients With Insulinoma: Caveats for Diagnosis Academic Article Article uri icon


MeSH Major

  • Dependovirus
  • Factor VIII
  • Genetic Therapy
  • Genetic Variation
  • Genetic Vectors
  • Hemophilia A


  • Two patients with insulinomas had unusual glucose and insulin-secretory dynamics in response to prolonged fasting. In patient 1, low insulin values persisted throughout three separate supervised fasts without a steady rise in the insulin-glucose ratio. In patient 2, a rising insulin-glucose ratio during a fast returned to normal after a documented catecholamine surge following a transient hypoglycemic episode. While patient 1 had clearly elevated proinsulin values of 52% to 57%, patient 2 had a near-normal value of 23%. The diagnosis of an insulinoma can usually be made by obtaining simultaneous glucose and insulin values during a prolonged supervised fast. Rarely, however, anomalous results may be obtained during supervised fasts of patients with insulinoma, and a broader range of diagnostic tests will be required to establish the correct diagnosis.

publication date

  • January 1985



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1001/archinte.1985.00360100127021

PubMed ID

  • 2994586

Additional Document Info

start page

  • 1861

end page

  • 3


  • 145


  • 10