Targeting the vasculature to improve neural progenitor transplant survival Review uri icon

Overview

MeSH Major

  • Epigenesis, Genetic
  • Gene Expression Regulation
  • Neuralgia
  • Repressor Proteins

abstract

  • ©2015 Justin Hill, John Cave. Neural progenitor transplantation is a promising therapeutic option for several neurological diseases and injuries. In nearly all human clinical trials and animal models that have tested this strategy, the low survival rate of progenitors after engraftment remains a significant challenge to overcome. Developing methods to improve the survival rate will reduce the number of cells required for transplant and will likely enhance functional improvements produced by the procedure. Here we briefly review the close relationship between the blood vasculature and neural progenitors in both the embryo and adult nervous system. We also discuss previous studies that have explored the role of the vasculature and hypoxic pre-conditioning in neural transplants. From these studies, we suggest that hypoxic pre-conditioning of a progenitor pool containing both neural and endothelial cells will improve engrafted transplanted neuronal survival rates.

publication date

  • August 5, 2015

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC4936624

Digital Object Identifier (DOI)

  • 10.1515/tnsci-2015-0016

PubMed ID

  • 28123800

Additional Document Info

start page

  • 162

end page

  • 167

volume

  • 6

number

  • 1