Outcomes related to methotrexate dose and route of administration in patients with rheumatoid arthritis: A systematic literature review Review uri icon

Overview

MeSH Major

  • Arthritis, Rheumatoid
  • Immunosuppressive Agents
  • Methotrexate

abstract

  • Efficacy and toxicity for MTX appear related to absorbed dose of MTX, not to route of administration. While bioavailability is greater for parenteral MTX, there is no evidence yet that splitting the oral dose of MTX is less advantageous, less safe or less tolerable than administering parenteral MTX. However, there appear to be modest benefits in beginning with higher doses of MTX, and switching to parenteral MTX when the clinical response to an oral dose is inadequate.

publication date

  • January 2015

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC4406815

PubMed ID

  • 25536122

Additional Document Info

start page

  • 272

end page

  • 8

volume

  • 33

number

  • 2