Malnutrition, Immunodeficiency, and Mucosal Infection
© 2015 Elsevier Inc. All rights reserved. Dietary patterns, specific nutrients, and overall nutritional status are critical determinants of gastrointestinal microbial diversity, and regulate the development of the mucosal immune system. Genetic and epigenetic factors associated with the human gut metagenome interact with dietary factors to program and modify immune development. New studies show that nutrients influence the establishment of the microbiota during commensal colonization. Long-term dietary patterns affect the diversity of the microbiota, whereas short-term changes in diet influence mechanisms of immune response. Emerging studies suggest that the origins of obesity and growth faltering involve interaction between diet and microbes on the predominating microbial populations that influence host gene expression required for growth and immune development. Both obesity and malnutrition lead to mucosal immune deficiencies including misdirected tolerance, autoimmune responses, and chronic inflammation. How these encounters affect susceptibility to disease, including those caused by infectious pathogens, can now be examined in new ways.
Digital Object Identifier (DOI)
Additional Document Info
has global citation frequency