PET imaging of tumor-associated macrophages with 89Zr-labeled high-density lipoprotein nanoparticles Academic Article uri icon

Overview

MeSH Major

  • Lipoproteins, HDL
  • Nanoparticles
  • Positron-Emission Tomography
  • Radioisotopes
  • Zirconium

abstract

  • We have developed (89)Zr-labeled TAM imaging agents based on the natural nanoparticle rHDL. In an orthotopic mouse model of breast cancer, we have demonstrated their specificity for macrophages, a result that was corroborated by flow cytometry. Quantitative macrophage PET imaging with our (89)Zr-rHDL imaging agents could be valuable for noninvasive monitoring of TAM immunology and targeted treatment.

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4737475

Digital Object Identifier (DOI)

  • 10.2967/jnumed.115.158956

PubMed ID

  • 26112022

Additional Document Info

start page

  • 1272

end page

  • 7

volume

  • 56

number

  • 8