Neutrophil gelatinase-associated lipocalin and innate immune responses to bacterial infections Review uri icon

Overview

MeSH Major

  • Acute-Phase Proteins
  • Bacterial Infections
  • Immunity, Innate
  • Lipocalins
  • Neutrophils
  • Proto-Oncogene Proteins

abstract

  • Neutrophil gelatinase-associated lipocalin (NGAL), an essential component of the antimicrobial innate immune system, is present in neutrophils and multiple other tissues. It prevents iron acquisition by microorganisms by sequestering iron-loaded bacterial siderophores. NGAL also modulates neutrophil functions. Its production is inducible following Toll-like receptor 4 activation and release of pro-inflammatory cytokines. NGAL is employed clinically in the diagnosis of acute kidney injury and may be useful in general in the differential diagnosis of a bacterial-mediated infectious process. Elevated levels of NGAL have been detected in the blood of patients with bacterial urinary tract infection, community-acquired pneumonia, sepsis, as well as in the cerebrospinal fluid and peritoneal fluid of patients with bacterial meningitis and peritonitis. Some bacteria have developed resistance to NGAL-mediated iron sequestration by production of modified siderophores that are not recognized by NGAL.

publication date

  • August 28, 2015

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1007/s00430-015-0394-1

PubMed ID

  • 25716557

Additional Document Info

start page

  • 471

end page

  • 9

volume

  • 204

number

  • 4