Novel insights into the biology and treatment of chronic myeloproliferative neoplasms Review uri icon

Overview

MeSH Major

  • Myeloproliferative Disorders
  • Protein Kinase Inhibitors
  • Protein-Tyrosine Kinases

abstract

  • Myeloproliferative neoplasms (MPNs) are clonal disorders of hematopoiesis characterized by a high frequency of genetic alterations, and include chronic myeloid leukemia (CML) and the BCR-ABL1-negative MPNs. Herein we summarize recent advances and controversies in our understanding of the biology and therapy of these disorders, as discussed at the 8th post-American Society of Hematology CML-MPN workshop. The principal areas addressed include the breakthrough discovery of CALR mutations in patients with JAK2/MPL wild type MPN, candidate therapies based on novel genetic findings in leukemic transformation and new therapeutic targets in MPNs, and an appraisal of bone marrow histopathology in MPNs with a focus on the potential new clinical entity of "masked" polycythemia vera. An update on clinical trials of Janus kinase (JAK) inhibitors is presented as well as current understanding regarding the definitions and mechanisms of resistance to JAK inhibitors, and updated information on the safety and efficacy of discontinuation of tyrosine kinase inhibitors in patients with CML.

publication date

  • January 2015

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC5076856

Digital Object Identifier (DOI)

  • 10.3109/10428194.2014.974594

PubMed ID

  • 25330439

Additional Document Info

start page

  • 1938

end page

  • 48

volume

  • 56

number

  • 7