A new era in idiopathic pulmonary fibrosis: considerations for future clinical trials. Academic Article uri icon

Overview

MeSH

  • Biomarkers
  • Disease Progression
  • Humans
  • Pulmonary Medicine
  • Research Design
  • Treatment Outcome

MeSH Major

  • Clinical Trials as Topic
  • Idiopathic Pulmonary Fibrosis

abstract

  • The past decade has seen substantial progress in understanding the pathobiology, natural history, and clinical significance of idiopathic pulmonary fibrosis (IPF), culminating in the establishment of two effective medical therapies. Now seems an important time to reconsider the design and conduct of future IPF clinical trials. Building on lessons learned over the past decade, we use this perspective to lay out four key considerations for moving forward effectively and efficiently with the next generation of clinical trials in IPF. These are: development of a coordinated IPF clinical trials network; establishment of expectations for early phase proof of concept studies; adaptation of late-phase efficacy trial designs to the emergence of approved therapies, and; agreement on primary end-points for late phase clinical trials. Continued progress in the field of IPF will require creativity and collaboration on the part of all stakeholders. We believe that addressing these four considerations will encourage and enable investment in this new era of drug development in IPF, and will lead to more rapid development of effective therapies. Copyright ¬©ERS 2015.

publication date

  • July 2015

has subject area

  • Biomarkers
  • Clinical Trials as Topic
  • Disease Progression
  • Humans
  • Idiopathic Pulmonary Fibrosis
  • Pulmonary Medicine
  • Research Design
  • Treatment Outcome

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1183/09031936.00200614

PubMed ID

  • 25900377

Additional Document Info

start page

  • 243

end page

  • 249

volume

  • 46

number

  • 1