Epigenetic targeting and personalized approaches for AML Review uri icon

Overview

MeSH Major

  • Epigenesis, Genetic
  • Leukemia, Myeloid, Acute
  • Precision Medicine

abstract

  • Acute myeloid leukemia (AML) is a genetically heterogeneous clonal hematopoietic stem cell disorder and the majority of patients with AML die from their disease. The treatment paradigms for AML were developed decades ago and, although there have been improvements in the outcomes of selected younger patients and those with specific cytogenetic and molecular genetic characteristics, the overall survival for older patients remains dismal. Over the last few years, next-generation sequencing technologies have identified recurrent mutations in genes encoding proteins involved in the epigenetic regulation of transcription in most patients with AML. This discovery has led to new insights into the role of the epigenome in AML and opens the possibility of epigenetically targeted therapies. This chapter describes how epigenetic dysregulation plays a role in AML and highlights current and future treatment strategies that attempt to exploit epigenetic targets.

publication date

  • January 2014

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1182/asheducation-2014.1.44

PubMed ID

  • 25696833

Additional Document Info

start page

  • 44

end page

  • 51

volume

  • 2014

number

  • 1