Definitive and adjuvant radiotherapy in locally advanced non-small-cell lung cancer: American Society of Clinical Oncology clinical practice guideline endorsement of the American Society for Radiation Oncology evidence-based clinical practice guideline Academic Article uri icon


MeSH Major

  • Carcinoma, Non-Small-Cell Lung
  • Lung Neoplasms
  • Radiotherapy
  • Radiotherapy, Adjuvant


  • For curative-intent treatment of locally advanced NSCLC, concurrent chemoradiotherapy improves local control and overall survival compared with sequential chemotherapy followed by radiation. The standard dose-fractionation of radiation is 60 Gy given in 2-Gy once-daily fractions over 6 weeks. There is no role for the routine use of induction therapy before chemoradiotherapy. Current data fail to support a clear role for consolidation therapy after chemoradiotherapy; however, consolidation therapy remains an option for patients who did not receive full systemic chemotherapy doses during radiotherapy. Important questions remain about the ideal concurrent chemotherapy regimen and optimal management of patients with resectable stage III disease.

publication date

  • June 20, 2015



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.2014.59.2360

PubMed ID

  • 25944914

Additional Document Info

start page

  • 2100

end page

  • 5


  • 33


  • 18