Quantifying the importance of disease burden on perceived general health and depressive symptoms in patients within the Mayo Clinic Biobank
Quality of Life
Severity of Illness Index
Comorbid health burden has the strongest influence on deficits in self-perceived general health, while demographic factors show relatively minimal impact. For depressive symptoms, both age and comorbid health burden were equally important, with decreasing deficits in depressive symptoms with increasing age. For interpreting patient-reported metrics and comparison, one must account for comorbid health burden.